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pentobarbital will decrease the level or result of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Mysterious.Observe Intently (1)pentobarbital will decrease the extent or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Coadministration of fentanyl